This proposal plans to screen for and assess the prevalence of, and identify dominant emerging contaminants such as persistent organic compounds (POPs) and endocrine-disrupting substances (EDCs) in the Iloilo-Batiano river system. These chemicals are associated with plastic and pharmaceutical pollution among other anthropogenic activities. To our knowledge, no data on the prevalence of POPs and EDCs are available for the Iloilo-Batiano river system. Moreover, The COVID-19 pandemic would have increased the likelihood of the prevalence; in terms of the increased pharmaceutical waste due to the full-capacity operation of the major hospitals in the city, and the continuous use and disposal of face masks and face shields coupled with poor waste management. Soil and water samples collected in strategic sampling sites in the river system will be analyzed using the liquid chromatography quadrupole time-of-flight mass spectrometer (LCQTof-MS) at the University of the Philippines Visayas, Miagao Iloilo will be the main tool to screen for POPs and EDCs. The goal of this proposal is to screen for dominant POPs and EDC associated with Iloilo Cityś urbanization. These chemicals can serve as indicators of pollution and can be included in the successive water quality monitoring and assessments on ecological and human health.