As part of the DOST-PCHRD’s Tuklas Lunas framework, this proposal will focus on the medicinal plants utilized by the different ethnolinguistic groups in treating lifestyle related diseases. Such as hypertension, diabetes and cancer, which are the leading causes of mortality in the Philippines last 2018 and aggravated during the COVID-19 pandemic. This scientific validation of the medicinal plants’ effectiveness through laboratory experimentation will address the primary health care of the Filipinos especially in the rural setting where access to health care facilities is difficult and high-priced commercial medicines pose an added burden. Zamboanga Peninsula is rich in floral biodiversity and ethnolinguistically diverse. Traditionally, these are passed on to their descendants orally and not scientifically validated. Examples of these medicinal plants that still lack scientific validation are the Tinospora cordifolia Boerl (makabuhay/heavenly elixir) for diabetes, Morinda citrifolia L. (apatot/noni fruit) for cancer and Rauvolfia serpentina (L.) Kurz (serpentina/snakeroot) for hypertension (Madjos & Ramos, 2021a). The reports and narratives that can be generated from this project can be utilized for further research in extraction, isolation, and bioassay studies of medically active compounds. The project envisions of a more proactive conservation management involving the different ethnolinguistic groups in the Zamboanga Peninsula.